Uterine Fibroids

it becomes unnecessary due to the development of involutional processes (age hypotrophy and atrophy of the myometrium). Surgical treatment can not be considered optimal in all cases, as after radical surgery not only saved many neurohumoral changes, giving rise to the tumor, but also partly aggravated by somatic status of patients. At the heart of conservative treatment of uterine fibroids is the concept of hormone-dependent nature of this tumor, although the increase in estrogen and progesterone deficiency are not permanent factors in the development of fibroids. In the pathogenesis of uterine fibroids is set to the state of the receptor apparatus of the myometrium. In the myoma tissue the amount of bound estradiol reaches 60 – 65%, whereas the tissue-filled unchanged myometrium – 37%, which suggests a higher activity compared with estrogenretseptorov gestagenretseptorami.

The possibility of local production of estrogen in the myometrium, changes in cholinergic innervation also play a role in the pathogenesis of uterine fibroids (GA. Savitsky, etc.). The success of conservative therapy depends on early diagnosis and early treatment. Contra-indications for conservative treatment of uterine fibroids include: – The size of the uterus with nodes greater than 12-week pregnancy – submuzkoznoe location site and tsentripetalny growth interstitial site – rapid growth, causing suspicion of sarcoma of the uterus – a combination of uterine fibroids with ovarian tumors and adenomyosis – menorrhagia, causing anemia. Treatment should be comprehensive. First of all, it is aimed at inhibition of tumor growth. Therapy also provides for the correction of neuroendocrine disturbances, determine the causes and pathogenesis of fibroids; correction of physical status; elimination of symptoms, aggravating the disease.